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Study Suggests Unregulated Nano-sized Ultrafine Particles May Be Most Damaging Component of Air Pollution for Heart Disease
18 January 2008
A new study indicates that ultrafine particles—particles of less than 0.18 micrometers—from vehicle emissions may be the most damaging components of air pollution in triggering plaque buildup in the arteries, which can lead to heart attack and stroke. The findings appear in an open access article in the 17 January online edition of the journal Circulation Research.
A team from University of California, Los Angeles (UCLA); the University of Southern California; the University of California, Irvine; and Michigan State University contributed to the research, which was led by Dr. Andre Nel, UCLA’s chief of nanomedicine. The study was primarily funded by the National Institute of Environmental Health Sciences and the US Environmental Protection Agency (EPA).
It appears that the smallest air pollutant particles, which are the most abundant in an urban environment, are the most toxic. This is the first study that demonstrates the ability of nano-sized air pollutants to promote atherosclerosis in an animal model.
—Dr. Jesus Araujo, first author and assistant professor of medicine and director of environmental cardiology at the David Geffen School of Medicine at UCLA
The EPA currently regulates fine particles at 2.5 micrometers, but doesn’t monitor particles in the nano- or ultrafine range. These particles are too small to capture in a filter, so new technology must be developed to track their contribution to adverse health effects.
We hope our findings offer insight into the impact of nano-sized air pollutant particles and help explore ways for stricter air quality regulatory guidelines.
—Andre Nel
The UCLA research team previously reported that diesel exhaust particles interact with artery-clogging fats in low-density lipoprotein (LDL) cholesterol to activate genes that cause the blood-vessel inflammation that can lead to heart disease. (Earlier post.)
In the current study, researchers exposed mice with high cholesterol to one of two sizes of air pollutant particles from downtown Los Angeles freeway emissions and compared them with mice that received filtered air that contained very few particles.
The study, conducted over a five-week period, required a complex exposure design that was developed by teams led by Dr. Michael Kleinman, professor of community and environmental medicine at UC Irvine, and Dr. Constantinos Sioutas, professor of civil and environmental engineering at USC.
Researchers found that mice exposed to ultrafine particles exhibited 55% greater atherosclerotic-plaque development than animals breathing filtered air and 25% greater plaque development than mice exposed to fine-sized particles.
Pollutant particles are coated in chemicals sensitive to free radicals, which cause the cell and tissue oxidation. Oxidation leads to the inflammation that causes clogged arteries. Samples from polluted air revealed that ultrafine particles have a larger concentration of these chemicals and a larger surface area where these chemicals thrive, compared with larger particles, Sioutas noted.
Ultrafine particles may deliver a much higher effective dose of injurious components, compared with larger pollutant particles.
—Andre Nel
Scientists also identified a key mechanism behind how these air pollutants are able to affect the atherosclerotic process. Using a test developed by Dr. Mohamad Navab, study co-author and a UCLA professor of medicine, researchers found that exposure to air pollutant particles significantly decreased the anti-inflammatory protective properties of HDL cholesterol.
To explore if air particle exposure caused oxidative stress throughout the body—which is an early process triggering the inflammation that causes clogged arteries—researchers checked for an increase in genes that would have been activated to combat this inflammatory progression.
They found greater levels of gene activation in mice exposed to ultrafine particles, compared to the other groups. The next step will be to develop a biomarker that could enable physicians to assess the degree of cardiovascular damage caused by air pollutants or measure the level of risk encountered by an exposed person.
Previous studies assessing the cardiovascular impact of air pollution have taken place over longer periods of exposure time, such as five to six months. The current study demonstrated that ill effects can occur more quickly, in just five weeks.
The research team included investigators from the fields of nanomedicine, cardiology and genetics. Additional co-authors included Berenice Barajas, Xuping Wang, Brian J. Bennett and Ke Wei Gong of the David Geffen School of Medicine at UCLA, and Jack Harkema from the department of pathobiology and diagnostic investigation at Michigan State University.
Additional grant support was provided by the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; and the Robert Wood Johnson Foundation.
Resources
Jesus A. Araujo et. al. Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress. Circ. Res. published online Jan 17, 2008
Andre Nel, Tian Xia, Lutz Mädler, Ning Li. Toxic Potential of Materials at the Nanolevel. Science 3 February 2006: Vol. 311. no. 5761, pp. 622 - 627 DOI: 10.1126/science.1114397
January 18, 2008 in Diesel, Emissions | Permalink | Comments (35) | TrackBack (0)
Comments
Posted by: Roger Pham | January 22, 2008 at 12:04 PM
@ Rafael
There is some naturally-occurring ultrafine PM produced as SOA from biogenic VOC emissions (mostly alpha-pinenes from conifers; isoprenes from deciduous trees apparently don't produce much SOA).
Actually some level of ambient particles is critical for precipitation (rain, snow, etc.) events to occur (although not necessarily UF). They serve as condensation nuclei (heterogeneous nucleation of water vapor). Without condensation nuclei, homogeneous nucleation would be the only way for WV to condense, and that occurs at about -40 degrees C. Virtually the entire earth would likely be a desert under those conditions.
@dt
You’re correct and I should have been more specific about particle NUMBER emissions being equaled or exceeded by gasoline engines relative to uncontrolled diesel engines under certain common driving conditions.
@joe padula and Roger
CNG has been shown to produce ultrafine PM emissions that generally exceed clean diesel in several bus studies (including CARB which is certainly not a diesel proponent). On top of that, the UF PM from CNG is about 7 times more mutagenic than the UF from clean diesel buses, and CNG produces higher emissions of virtually every other pollutant with the possible exception of NOx, even with an oxidation catalyst. I haven’t seen any studies that looked specifically at light-duty CNG vehicles, but extrapolating the CNG bus studies casts some doubt on those also (at least as being a better option than clean diesel).
IIRC, there was a post here on GCC a while back that mentioned a study that even hydrogen ICEs produce UF PM, apparently from the lube oil that is consumed.
In my opinion, clean diesel is the best option at this time, at least until EVs are ready for prime time.
Posted by: Carl | January 22, 2008 at 03:20 PM
Carl,
Your assertion that CNG combustion produces higher emissions of virtually every pollutants than clean diesel simply flies on the face of common sense.
CNG combustion, when properly regulated, is the cleanest of all hydrocarbon. The methane molecule is so simple and so easily combusted that the likelyhood of formation of carcinogenic compounds would be nil, unlike long-chain hydrocarbon liquid fuels like diesel fuel, and aromatic compounds in gasoline. In fact, I would seriously question the contention that modern gasoline engines produce just as much but finer particles as diesels, unless the engine is out of tune! A good oxidative catalyst when properly functioning, can burn a substantial number of these fine hydrocarbon particles. The finer they are, the easier to burn them off into CO2 and H2O. The more reactive free radicals they have, the easier it would be to render them inert in the catalytic converter.
Adding H2 to methane (hythane) can further make methane combustion even cleaner. For advanced ICE that does not consume oil, or very little oil, the PM emission from oil combustion would be zero, or nearly so.
References to support your assertion, please.
Posted by: Roger Pham | January 22, 2008 at 07:50 PM
@ Roger
Here are a few references concerning the CNG vs. clean diesel bus studies:
http://www.osti.gov/bridge/servlets/purl/829623-F0uIqi/native/829623.pdf
http://www.wspa.org/pdfs/fuels_Diesel_Update_Final.pdf
The hydrogen study I mentioned was from memory, which at my age probably isn't very reliable. Anyone else remember that post?
As far as the gasoline vs. diesel ultrafine emissions, please see the University of Minnesota study I referenced in my first post.
Posted by: Carl | January 22, 2008 at 08:15 PM
Carl thanks for the reasoned analysis backed by substantive research. It's always nice to have factual information trump what's touted as common sense. By the way is this the Hydrogen article of which you speak?
http://www.greencarcongress.com/2007/10/study-lube-oil-.html
A
Posted by: winnipeg BioD | January 22, 2008 at 11:16 PM
excerpt from Carl's reference, on the bottom of page 5 of 20:
http://www.wspa.org/pdfs/fuels_Diesel_Update_Final.pdf
"These studies were designed to characterize
emissions for individual heavyduty
vehicles, and thus do not represent
average emissions for the entire
fleet of heavy-duty vehicles. Also, the
CNG and clean diesel technologies are
both extremely low-emitting systems
and therefore challenge the sampling
and analytical methodologies to the
limits of detection."
Carl,
Both CNG engine with oxadative catalyst and diesel with PDF are considered to have extremely low toxic emission near the limit of detection, and hence are considered to be equivalent, due to imprecision in sampling. It would be like splitting hair in saying which one is better than the other.
What more relevant is the high cost of Diesel fuel AND the cost of Diesel DPF over a give period of time in use, in comparison to the much lower energy cost of CNG fuel and the abscence of the very expensive DPF AND of NOx treatment for diesel. CNG engine inherently produces much lower NOx level than Diesel.
CNG wins hands down, no question needs be asked!
Posted by: Roger Pham | January 23, 2008 at 12:05 AM
@ winnipeg BioD
That's it! Thanks.
@ Roger
I completely agree that both CNG/OC and clean diesel are exceptionally low in emissions. I'm just responding to the numerous comments here on GCC that imply that diesel is the sole source of ambient PM, ultrafine or otherwise.
By the way, according to a NYC bus study (CNG vs. clean diesel), it doesn't appear that CNG has any advantage from a cost perspective over clean diesel either. See http://www1.eere.energy.gov/vehiclesandfuels/pdfs/deer_2003/session5/deer_2003_lowell.pdf
Posted by: Carl | January 23, 2008 at 07:11 AM
Love to see so much commotion over this issue. May ICE die, that people live. Long live EVs.
Great to see research extensions for other Internal Combustion Vehicles following Prof. Mark Jacobson's E85 pollution study as reported in GCC on April 18, 2007.
Instead of the ICE numbers of particles being quoted here, more knowledge needs to concentrate on victims of pollution...you know...coughing blood & young lungs that can't use the oxygen in the air anymore.
Roger Pham...Do not fear. Only you have talked about political abolition of ICE. Even my comment only refers to 'death to ICE' by economic, not political means. So lets work hard to get electric energy densities way up, charge times way down, renewable electric sources way many & EVs on the road. Then, ICE will die(economically), that people will live. Long live EVs.
Posted by: litesong | January 23, 2008 at 08:59 AM
Any thoughts on Energy from waste (incinerators) and there nano-particulates. Is it fair to believe that these will contribute fine dust to surrounding areas. We have a local council trying to bring one into our area and we have concerns.
Posted by: russ | February 20, 2008 at 07:06 PM
"Posted by: arnold | Jan 20, 2008 7:21:02 PM
I'm curious whether the ultrafine particulate issue would be different for biodiesel. Anyone know?
50 mpg on biodiesel made from non-edible feedstocks is still a decent short to medium-term option while we wait for affordable BEVs. Or at least I hope it is..."
From what I've read in British news is that bio-diesel is better than existing diesel, but not free from Small Particle Pollution or Ultra Fine Particle Pollution. Both cause problems, but the specific problems of the Ultra-fine have been pinpointed in this report. I think more of the cloud like haze that hangs over Disneyland, than normal diesel exhaust with the Ultra-Fine. Small Particle is more what I think of with diesel, and combustion. My personal images of sources may be wrong, but both size particles are bad for health.
Posted by: A CA Girl | February 21, 2008 at 11:25 AM
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To those who advocate abolition of the ICE, please don't throw the baby out with the bath water! The problem, gentlemen, is with the liquid hydrocarbon, NOT with the ICE. Use gaseous fuels like hydrogen, methane, or the combination of both, and this problem will be much ameliorated.
Guess who has been advocating Hydrogen and methane ICE all along here in GCC?