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Air pollution exposure during fetal life linked to brain alterations and cognitive impairment in children

A new study performed in the Netherlands has linked exposure to residential air pollution during fetal life with brain abnormalities that may contribute to impaired cognitive function in school-age children. The study, published in Biological Psychiatry, reports that the air pollution levels related to brain alterations were below those considered to be safe.

Exposure to fine particles during fetal life was associated with a thinner outer layer of the brain (the cortex) in several regions. The study showed that these brain abnormalities contribute in part to difficulty with inhibitory control—the ability to regulate self-control over temptations and impulsive behavior—which is related to mental health problems such as addictive behavior and attention-deficit/hyperactivity disorder.

This finding adds to previous studies that have linked acceptable air pollution levels with other complications including cognitive decline and fetal growth development.

We observed brain development effects in relationship to fine particles levels below the current EU limit. Therefore, we cannot warrant the safety of the current levels of air pollution in our cities.

—lead author Mònica Guxens, MD

The study used a population-based cohort in Rotterdam, The Netherlands, which enrolled pregnant women and followed the children from fetal life onward. Dr. Guxens and colleagues assessed air pollution levels at home during the fetal life of 783 children. The data were collected by air pollution monitoring campaigns, and included levels of nitrogen dioxide (a prominent air pollutant caused by traffic and cigarette smoking), coarse particles, and fine particles.

Brain imaging performed when the children were between 6 and 10 years old revealed abnormalities in the thickness of the brain cortex of the precuneus and rostral middle frontal region. Despite the relationship between these brain structure alterations and fine particle exposure, the average residential levels of fine particles in the study—20.2μg/m3 (range 16.8-28.1)—were well below the current acceptable limit set by the EU—only 0.5% of the pregnant women in the study were exposed to levels considered unsafe. The average residential levels of nitrogen dioxide were right at the safe limit.

Children exposed to higher particulate matter levels during fetal life had thinner cortex in several brain regions of both hemispheres (e.g. cerebral cortex of the precuneus region in the right hemisphere was 0.045mm thinner (95% Confidence Interval 0.028-0.062) for each 5μg/m3 increase in fine particles). The reduced cerebral cortex in precuneus and rostral middle frontal regions partially mediated the association between exposure to fine particles and impaired inhibitory control. Air pollution exposure was not associated with global brain volumes.Guxens et al.

Air pollution is so obviously bad for lungs, heart, and other organs that most of us have never considered its effects on the developing brain. But perhaps we should have learned from studies of maternal smoking that inhaling toxins may have lasting effects on cognitive development.

—John Krystal, MD, Editor of Biological Psychiatry

The fetal brain is particularly vulnerable during pregnancy; it hasn’t yet developed the mechanisms to protect against or remove environmental toxins. The findings of the study suggest that exposure to levels even below those considered safe could cause permanent brain damage.

Although specific individual clinical implications of these findings cannot be quantified, based on other studies, the observed cognitive delays at early ages could have significant long-term consequences such as increased risk of mental health disorders and low academic achievement, in particular due to the ubiquity of the exposure.

—Dr. Guxens

Resources

  • Guxens M., Lubczyńska M.J., Muetzel R., Dalmau-Bueno A., Jaddoe V.W.V., Hoek G., van der Lugt A., Verhulst F.C., White T., Brunekreef B., Tiemeier H. & El Marroun H. (2018) “Air pollution exposure during fetal life, brain morphology, and cognitive function in school-age children” Biological Psychiatry doi: 10.1016/j.biopsych.2018.01.016

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