A team of researchers in Germany has sequenced the genome of the anaerobic bacterium Clostridium kluyveri, a well-studied organism unique among the clostridia in that it grows on ethanol and acetate as sole energy sources. Fermentation products are butyrate, caproate, and hydrogen.
|Circular representation of the chromosome and plasmid of C. kluyveri. Click to enlarge.|
The scientists from the Max Planck Institute for Terrestrial Microbiology; Göttingen Genomics Laboratory, Georg August University; and Fachbereiche Chemie and Biologie, Philipps-Universität report their work in an open access article in the current online edition of the Proceedings of the National Academy of Sciences.
The sequencing provided new insights into the fermentation strategy of C. kluyveri to convert ethanol and acetate to butyrate, caproate, and H2. All of the genes required for the metabolic pathway were found.
Henning Seedorf, et. al. The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features. PNAS, published online 12 Feb 2008, DOI: 10.1073/pnas.0711093105