The committee that wrote the report was not asked to consider how evidence has been used by EPA to set ozone standards, including the new public health standard set by the agency last month.

Ozone, a key component of smog, can cause respiratory problems and other health effects.  In addition, evidence of a relationship between short-term—less than 24 hours—exposure to ozone and mortality has been mounting, but interpretations of the evidence have differed, prompting EPA to request the Research Council report.  In particular, the agency asked the committee to analyze the ozone-mortality link and assess methods for assigning a monetary value to lives saved for the health-benefits assessments.

Based on a review of recent research, the committee found that deaths related to ozone exposure are more likely among individuals with pre-existing diseases and other factors that could increase their susceptibility.  However, premature deaths are not limited to people who are already within a few days of dying.

In addition, the committee examined research based on large population groups to find how changes in ozone air concentration could affect mortality, specifically to determine the existence of a threshold—a concentration of ozone below which exposure poses no risk of death.  The committee concluded that if a threshold exists, it is probably at a concentration below the current public health standard.  As people have individual susceptibilities to ozone exposure, not everyone may experience an altered risk of death if ozone air concentration also changes.  Further research should explore how personal thresholds may vary and the extent to which they depend on a person’s frailty, the committee said.

The research on short-term exposure does not account for all ozone-related mortality, and the estimated risk of death may be greater than if based solely on these studies, the committee noted.  To better understand all the possible connections between ozone and mortality, future research should address whether exposure for more than 24 hours and long-term exposure—weeks to years—are associated with mortality, including how ozone exposure could impact life expectancy.  For example, deaths related to short-term exposure may not occur until several days afterward or may be associated with multiple short-term exposures.

Additionally, EPA should monitor ozone during the winter months when it is low and in communities with warmer and cooler winters to better understand seasonal and regional differences in risk.  More research could also look at how other pollutants, such as airborne particulate matter, may affect ozone and mortality risk.

The study was sponsored by the US Environmental Protection Agency.  The National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council make up the National Academies.  They are private, nonprofit institutions that provide science, technology, and health policy advice under a congressional charter.  The Research Council is the principal operating agency of the National Academy of Sciences and the National Academy of Engineering.

Resources

• Estimating Mortality Risk Reduction and Economic Benefits from Controlling Ozone Air Pollution