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BCV and Senesco enter into license agreement for the application of gene regulation technology to energy crops

BioCorp Ventures LLC (BCV), a division of technology incubator US Equity Holdings, and Senesco Technologies, Inc. have entered into an R&D agreement to use Senesco’s proprietary eukaryotic translation initiation Factor 5A (eIF5A) technology platform for sustainable energy applications. BCV was specifically formed in 2011 to license biofuel applications of technology developed by Senesco.

BCV will have a license to evaluate Senesco’s technology for the development of plants and plant products suitable for use in the production of biofuel and biofuel feedstock, including all species of algae and all species in the genus Miscanthus (perennial grasses). The companies will continue ongoing research and development as BCV works on commercializing the technology.

BCV will be fully responsible for further assessing the potential of the Senesco technology for all biofuel applications and determining the route to the commercialization of biofuel products. Through its know-how at the University of Waterloo, Senesco will be responsible for technology transfer and providing technical advice to facilitate BCV operations.

After the initial evaluation phase, the agreement provides annual license maintenance payments to Senesco and royalty payments if a product is commercialized by BCV. As part of the agreement, Senesco has a 15% equity interest in BCV and the right to appoint one member to BCV’s advisory board.

Low-cost, environmentally friendly biofuels will be increasingly valuable as the world moves to a low-carbon future. We are embarking on a critical evaluation phase that will tell us just how powerful Senesco’s technology can be in developing enhanced plant strains that enable biofuels to be produced in an efficient and environmentally responsible way. Senesco’s technology has been licensed in other biotech industries to well-known companies such as Monsanto and Bayer CropScience so we believe that the underlying technology can yield favorable results in biofuels.

—Chester Aldridge, Chairman of US Equity Holdings

Senesco has been developing gene regulation technologies that may be useful in generating strains of biofuel-yielding organisms with superior growth characteristics. Senesco and other licensees have demonstrated that its technology has the potential to enhance size, yields and resistance to stress, like drought, salinity and disease in plants.

Starting in 1999, Senesco has entered into license agreements with leading-edge companies engaged in agricultural biotechnology, including Monsanto and Bayer CropScience, who are applying Senesco technology in product development in important crops including rice, soy and cotton. Senesco has strong intellectual property with 102 issued patents, covering multiple compositions of matter and methods of use.

Senesco Technologies is leveraging proprietary technology that regulates programmed cell death, or apoptosis. Accelerating apoptosis may have applications in treating cancer, while delaying apoptosis may have applications treating certain inflammatory and ischemic diseases. The Company has initiated a clinical study in multiple myeloma with its lead therapeutic candidate SNS01-T. Senesco has already partnered with leading-edge companies engaged in agricultural biotechnology, and is entitled to earn research and development milestones and royalties if its gene-regulating platform technology is incorporated into its partners’ products.

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