Researchers with the US Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), China’s Shanghai Institute of Organic Chemistry and Fudan University have unveiled the first two-dimensional supramolecular organic frameworks (SOFs) that self-assemble in solution, an important breakthrough that holds implications for sensing and separation technologies, energy sciences, and, perhaps most importantly, biomimetics.
Supramolecular chemistry, in which molecules and molecular complexes are held together by non-covalent bonds, is just beginning to come into its own with the emergence of nanotechnology.
We’ve demonstrated the first soluble single-layer 2D honeycomb SOF that combines the ordering and porous features of MOFs [metal-organic frameworks] with the solubility of supramolecular polymers. The results prove that we can exercise precise control of dimensionality within structures through a solution-based supramolecular approach, which paves the way for the assembly of more advanced architectures that can be processed in solution.—Yi Liu, a chemist with Berkeley Lab’s Materials Sciences Division
Liu, who oversees the supramolecular electronics research group at Berkeley Lab’s Molecular Foundry, a DOE national nanoscience user facility, is one of three corresponding authors of a paper describing this research in the Journal of the American Chemical Society (JACS). The other corresponding authors are Xin Zhao and Zhan-Ting Li, of the Shanghai Institute of Organic Chemistry and Fudan University.
Traditional molecular chemistry involves the strong covalent bonds formed by the sharing or exchange of electrons between the atoms that make up a molecular system. Supramolecular chemistry involves systems that are held together by a multitude of weaker, non-covalent connections, such as hydrogen bonds and electrostatic and Van der Waals forces. Nature uses supramolecular chemistry to form the double-helix of DNA or to fold proteins. For nanotechnology, single-layers of 2D structurally ordered materials—along the lines of graphene—could fill a great many needs but the key is to process them in solution.
Solution-based processing allows for mass production and reduced manufacturing costs, and is an important step for transferring materials to a dry state without losing their structural integrity. Solution-based processing also allows for bio-related applications such as biomimetic sensing, where the framework structure is advantageous for the capturing of guest molecules and the amplification of chemical signals.—Yi Liu
SOFs feature a porous framework with honeycomb periodicity similar to a MOF. However, the self-assembly of well-defined 2D supramolecular systems polymers in solution has been a challenge because such polymers tend to precipitate out of solution, making them difficult to manipulate and characterize. To meet this challenge, Yi and his collaborators used a combination of self-assembling tripods and marocycle rings to form a porous framework with honeycomb periodicity, similar to that of a MOF, but which remains rigid in solution. Equipping the tripods with bulky hydrophilic groups that resist stacking preserved the solubility and single-layer 2D architecture of the framework.
The tripods of these SOFs were made from aromatic bipyridine molecules whose trio of struts or arms were interlocked with the struts of their neighboring molecules through the macrocycles, which were made from cucurbituril molecules. The molecules used in this study were proof-of-principle starters. Other molecules for the struts could be employed in the future for the design of similar or more complex architectures. The 2D single-layer structures of these first SOFs were characterized at Berkeley Lab’s Advanced Light Source, another DOE national user facility, using small angle X-ray scattering (SAXS) technologies at beamlines 12.3.1 and 7.3.3.
Yi and his collaborators at the Molecular Foundry and in Shanghai are now working to create soluble SOFs in 3D. In addition to the corresponding authors, other authors of the JACS paper were Kang-Da Zhang, Jia Tian, David Hanifi, Yuebiao Zhang, Andrew Chi-Hau Sue, Tian-You Zhou and Lei Zhang.
This research was supported by the DOE Office of Science.
Kang-Da Zhang, Jia Tian, David Hanifi, Yuebiao Zhang, Andrew Chi-Hau Sue, Tian-You Zhou, Lei Zhang, Xin Zhao, Yi Liu, and Zhan-Ting Li (2013) “Toward a Single-Layer Two-Dimensional Honeycomb Supramolecular Organic Framework in Water.” Journal of the American Chemical Society 2013 135 (47), 17913-17918 doi: 10.1021/ja408693