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INVISTA and LanzaTech make breakthrough for bio-derived butadiene production; metabolic toolkit

INVISTA and LanzaTech have developed a metabolic toolkit that has been successfully applied to generate novel metabolic pathways to bio-derived butadiene and key precursors, such as 1,3 butanediol and 2,3 butanediol, resulting in new direct and 2-step processes for butadiene utilizing gas-fermentation technology. Butadiene is a key intermediate chemical used in the production of synthetic rubber and various plastics.

A metabolic toolkit integrates detailed knowledge about a bacterium’s genetic configuration with the tools to customize precisely that configuration in order to make a particular product, together with a model to accurately predict the performance of the bacterium. This work is in an early stage of development with an aim to commercialize within the next several years.

Butadiene is used by INVISTA in its proprietary, butadiene-based adiponitrile (ADN) production technologies. ADN is a critical intermediate chemical used in the manufacture of nylon 6,6.

This breakthrough highlights the value a metabolic toolkit can bring in developing new pathways for bio-based and bio-derived chemical production.

The work with INVISTA represents a significant step in integrating the chemicals supply chain into a circular economy model. By utilizing waste carbon resources, we are decoupling the production of butadiene from today’s commodity feedstocks.

—Jennifer Holmgren, CEO of LanzaTech

INVISTA believes biotechnology has the potential to significantly improve the cost and availability of several chemicals and raw materials that are used to produce its current products. It views gas fermentation as a key enabling technology that will allow the use of potentially advantaged gas feedstocks, such as waste industrial gases including carbon monoxide and carbon dioxide.

INVISTA and LanzaTech first announced their gas fermentation collaboration efforts in 2012.

LanzaTech’s proprietary gas fermentation technology provides an economic route to fuels and high-value chemicals by recycling waste carbon streams.


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