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Study: even relatively low levels of air pollution appear to affect a child’s lungs

In a paper published in the American Journal of Respiratory and Critical Care, researchers report that children exposed to higher levels of air pollution—even if relatively low—including fine particulate matter (PM2.5) and soot (black carbon), had worse lung function than those living in less polluted areas. By age eight, the lung function of children living within 100 meters of a major roadway was on average 6% lower than that of children living 400 meters or more away.

Residential proximity to roadway, and prior-year and lifetime PM2.5 and BC exposure were all associated with lower FVC [forced vital capacity, a lung function test]. Associations with FEV1 [forced expiratory volume] were also negative and proportionally similar. Pollution exposures were not associated with the FEV1/FVC ratio, or bronchodilator response. Compared to >400 m, living <100 m from a major roadway was associated with lower FVC (-98.6 mL; -176.3, -21.0). Each 2 μg/m3 increment in prior-year PM2.5 was associated with lower FVC (-21.8 mL; -43.9, 0.2) and higher odds of FEV1 < 80% predicted (1.41; 1.03, 1.93). Each 0.2 μg/m3 increment in prior-year BC was associated with a 38.9 mL (-70.4, -7.3) lower FVC.

—Rice et al.

Few studies have examined childhood exposure to air pollution after the dramatic improvements in air quality of the 1990's to see if exposure to air pollution at these lower levels is linked to children's lung function.

—Mary B. Rice, MD, MPH, an instructor at Harvard Medical School and lead author

Dr. Rice noted that PM2.5 levels in Boston have declined by more than 30% between 1996 and 2006.

The researchers studied 614 children born to mothers who enrolled between 1999 and 2002 in Project Viva, a long-term study of women’s and children’s health in eastern Massachusetts. Authors calculated the distance from the child’s home to the nearest major highway, and estimated first year of life, lifetime and prior-year exposure to PM2.5, using satellite measurements. They also estimated first year of life, lifetime and prior-year exposure to black carbon using 148 monitoring stations.

At age eight, children underwent lung function tests. Researchers found:

  • Children living the closest to major highways had the greatest reductions in their lung function.

  • Recent air pollution exposures most negatively impacted lung function measures.

  • Children who experienced greater improvements in air quality after the first year of life (either due to a move or changes in local pollution around the home) had better lung function compared to those whose air quality did not improve as much.

These important findings are from a novel study combining modern modeling of exposures to air pollution with robust measurements of lung function, conducted in a community with pollutant levels now under EPA standards. This adds to the urgency for more work to understand the impacts of these low-level exposures on human health.

— Cora S. Sack, MD, and Joel D. Kaufman, MD, MPH, of the University of Washington, in an accompanying editorial

Study limitations include the fact that lung function was measured only once and a relatively homogenous study population.

The study will follow these children into adolescence.

We plan to evaluate if the benefits of cleaner air endure by investigating if children with the greatest improvements in air quality continue to have better lung function than their peers in the teen years.

—Dr. Rice

Resources

  • Mary B Rice, Sheryl L. Rifas-Shiman, Augusto A Litonjua, Emily Oken, Matthew W. Gillman, Itai Kloog, Heike Luttmann-Gibson, Antonella Zanobetti, Brent A Coull, Joel Schwartz, Petros Koutrakis, Murray A. Mittleman, and Diane R Gold (2015) “Lifetime Exposure to Ambient Pollution and Lung Function in Children” American Journal of Respiratory and Critical Care Medicine doi: 10.1164/rccm.201506-1058OC

Comments

HarveyD

It is becoming more an more evident that newborns and children brain and body are more an more negatively affected by the environment their mother (and father?) lived in?

This is confirmed by the rising number of autisms, other brain impairment, social misfits, asthmatics, cancers.

Sooner or latter, we will have to replace corrective medicine with appropriate preventive measures, otherwise, the cost of preventive medicine will go sky high and/or many will have to live with serious pollution created defects.

Nirmalkumar

This is what YOGA andAyurvedic Indian system. It builds immunity and improves body system intead of correction. It is time world realises that we pay heavily for even mild levels of pollution.we have to shift to alternate systems, faster the better.

HarveyD

Curative medicine/drugs often create more sources of temporary ills and defects.

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