The US Department of Energy’s Bioenergy Technologies Office (BETO) has established the Agile BioFoundry (ABF)—a new consortium of nine Energy Department national laboratories working to standardize and streamline the entire biomanufacturing pipeline by uniting computer-assisted biological pathway design, process integration, process scale-up, and machine learning.
Lawrence Berkeley National Laboratory is leading the consortium. The national laboratories have a unique capability to provide facilities and tools and to share the cumulative knowledge gained to accelerate progress in both public and private sectors. This coordinated public effort will aid in efficiently realizing BETO’s goal to commercialize biofuels and renewable chemicals.
The ABF, with $35 million requested for fiscal year 2017, will achieve its goals by developing a system for product development and commercialization that will be broadly applicable to many bioproducts. The system will be an iterative Design-Build-Test-Learn process that involves the following:
Design—Selecting microorganisms and biochemical pathways through integrated analysis, and planning how to achieve increased product output using computer-assisted design
Build—Using molecular biology tools and laboratory automation to generate collections of microbial strains to be tested for improved performance
Test—Evaluating the strains generated using a multi-omics approach and process integration
Learn—Compiling the results to inform future experiments using advanced statistical algorithms and machine learning.
The ABF hopes to achieve a 40% reduction in energy intensity and 60% reduction in carbon intensity over current manufacturing processes, and also has a goal of reducing product time to market by 50%. The ABF plans to serve as a resource for data, software tools, analytical and biological protocols, and economic analyses, disseminating information through its website. In addition, the ABF will seek to actively partner with industry to ensure that the latest developments in synthetic biology are broadly accessible, enabling bio-derived products to reach the market more quickly.
Development of the ABF is part of BETO’s Conversion Research and Development Program, which funds projects to develop technologies for converting biomass feedstocks into viable biofuels and bioproducts, moving toward an economically competitive and environmentally sustainable bioeconomy.