The Health Effects Institute (HEI) is making available to the public the database and material of the Multicenter Ozone Study in oldEr Subjects (MOSES). MOSES measured a large number of cardiovascular and respiratory endpoints in 87 healthy participants (60 years old on average) who were exposed to 0, 70, or 120 parts per billion ozone for 3 hours while exercising moderately.
In the interest of scientific transparency and to encourage the broadest possible use of the data and the material, HEI has set up a streamlined process to access the data and the material (subject to the limited quantities available).
The MOSES database resides on the Harvard Dataverse public repository and may be accessed by anyone who is interested, without restrictions. Access to the database requires an initial log-in step that includes a brief questionnaire and terms and conditions for publications resulting from the research. Subsequent access to the supporting documentation (including the programming guide), to excel files, and to the MOSES final report does not require logging in.
The MOSES material consists of blood and plasma samples for all 87 subjects. These are stored at a commercial repository. A small number of sputum samples is stored at the MOSES Sputum Core Lab at the University of North Carolina at Chapel Hill and is also made available. Any qualified researcher from a not-for-profit US research center interested in doing specific analyses can request the samples.
HEI has delegated the Original Investigators to be custodians of the material and make decisions on their distribution and use, and to keep HEI informed of all requests and disposition of the material. Interested researchers should submit a short Material Request Form to the MOSES Original Investigators and sign a Material Transfer Agreement.