A study by a team from Washington University School of Medicine in St. Louis and the Veterans Affairs (VA) St. Louis Health Care System links PM2.5 pollution—even at levels deemed safe—to an increased risk of diabetes globally.
The open-access findings, published in the journal The Lancet Planetary Health, raise the possibility that reducing particulate pollution may lead to a drop in diabetes cases in heavily polluted countries such as India and less polluted ones such as the United States.
Diabetes is one of the fastest growing diseases, affecting more than 420 million people worldwide and 30 million Americans. The main drivers of diabetes include eating an unhealthy diet, having a sedentary lifestyle, and obesity, but the new research indicates the extent to which outdoor air pollution plays a role.
Our research shows a significant link between air pollution and diabetes globally. We found an increased risk, even at low levels of air pollution currently considered safe by the US Environmental Protection Agency (EPA) and the World Health Organization (WHO). This is important because many industry lobbying groups argue that current levels are too stringent and should be relaxed. Evidence shows that current levels are still not sufficiently safe and need to be tightened.—Ziyad Al-Aly, MD, the study’s senior author and an assistant professor of medicine at Washington University
While growing evidence has suggested a link between air pollution and diabetes, researchers have not attempted to quantify that burden until now.
Previous studies have found that PM2.5 particles can enter the lungs and invade the bloodstream, contributing to major health conditions such as heart disease, stroke, cancer and kidney disease. In diabetes, pollution is thought to reduce insulin production and trigger inflammation, preventing the body from converting blood glucose into energy that the body needs to maintain health.
Overall, the researchers estimated that pollution contributed to 3.2 million new diabetes cases globally in 2016—about 14% of all new diabetes cases globally that year. They also estimated that 8.2 million years of healthy life were lost in 2016 due to pollution-linked diabetes, representing about 14% of all years of healthy life lost due to diabetes from any cause. (The measure of how many years of healthy life are lost is often referred to as “disability-adjusted life years.”)
In the United States, the study attributed 150,000 new cases of diabetes per year to air pollution and 350,000 years of healthy life lost annually.
The Washington University team, in collaboration with scientists at the Veterans Affairs’ Clinical Epidemiology Center, examined the relationship between PM2.5 and the risk of diabetes by first analyzing data from 1.7 million U.S. veterans who were followed for a median of 8.5 years. The veterans did not have histories of diabetes.
The researchers linked that patient data with the EPA’s land-based air monitoring systems as well as space-borne satellites operated by the National Aeronautics and Space Administration (NASA). They used several statistical models and tested the validity against controls such as ambient air sodium concentrations, which have no link to diabetes, and lower limb fractures, which have no link to outdoor air pollution, as well as the risk of developing diabetes, which exhibited a strong link to air pollution. This exercise helped the researchers weed out spurious associations.
Then, they sifted through all research related to diabetes and outdoor air pollution and devised a model to evaluate diabetes risk across various pollution levels.
Finally, they analyzed data from the Global Burden of Disease study, which is conducted annually with contributions from researchers worldwide. The data helped to estimate annual cases of diabetes and healthy years of life lost due to pollution.
The researchers also found that the overall risk of pollution-related diabetes is tilted more toward lower-income countries such as India that lack the resources for environmental mitigation systems and clean-air policies. For example, poverty-stricken countries facing a higher diabetes-pollution risk include Afghanistan, Papua New Guinea and Guyana, while richer countries such as France, Finland and Iceland experience a lower risk. The US experiences a moderate risk of pollution-related diabetes.
In the US, the EPA’s PM2.5 pollution threshold is 12 micrograms per cubic meter of air, the highest level of air pollution considered safe for the public, as set by the Clean Air Act of 1990 and updated in 2012. However, using mathematical models, Al-Aly’s team established an increased diabetes risk at 2.4 micrograms per cubic meter of air.
Based on VA data, among a sample of veterans exposed to pollution at a level of between 5 to 10 micrograms per cubic meter of air, about 21% developed diabetes. When that exposure increases to 11.9 to 13.6 micrograms per cubic meter of air, about 24% of the group developed diabetes. A difference of three percentage points appears small, but it represents an increase of 5,000 to 6,000 new diabetes cases per 100,000 people in a given year.
In October 2017, The Lancet Commission on pollution and health published a report outlining knowledge gaps on pollution’s harmful health effects. One of its recommendations was to define and quantify the relationship between pollution and diabetes.
Bowe, Benjamin et al. (2018) “The 2016 global and national burden of diabetes mellitus attributable to PM2.5 air pollution” The Lancet Planetary Health, Volume 2, Issue 7, e301 - e312 doi: 10.1016/S2542-5196(18)30140-2